RT Book, Section
A1 Botham, Kathleen M.
A1 Mayes, Peter A.
A2 Rodwell, Victor W.
A2 Bender, David A.
A2 Botham, Kathleen M.
A2 Kennelly, Peter J.
A2 Weil, P. Anthony
SR Print(0)
ID 1160189897
T1 Lipid Transport & Storage
T2 Harper's Illustrated Biochemistry, 31e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259837937
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160189897
RD 2024/04/24
AB OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Identify  the  four  major  groups  of  plasma  lipoproteins  and  the  four  major  lipid  classes  they  carry.Illustrate  the  structure  of  a  lipoprotein  particle.Indicate  the  major  types  of  apolipoprotein  found  in  the  different  lipoprotein  classes.Explain  that  triacylglycerol  from  the  diet  is  carried  to  the  liver  in  chylomicrons  and  from  the  liver  to  extrahepatic  tissues  in  very-low-density  lipoprotein  (VLDL),  and  that  these  particles  are  synthesized  in  intestinal  and  liver  cells,  respectively,  by  similar  processes.Illustrate  the  processes  by  which  chylomicrons  are  metabolized  by  lipases  to  form  chylomicron  remnants,  which  are  then  removed  from  the  circulation  by  the  liver.Explain  how  VLDL  is  metabolized  by  lipases  to  intermediate-density  lipoprotein  (IDL)  which  may  be  cleared  by  the  liver  or  converted  to  low-density  lipoprotein  (LDL),  which  functions  to  deliver  cholesterol  from  the  liver  to  extrahepatic  tissues  via  the  LDL  (apoB100,  E)  receptor.Explain  how  high-density  lipoprotein  (HDL)  is  synthesized,  indicate  the  mechanisms  by  which  it  accepts  cholesterol  from  extrahepatic  tissues  and  returns  it  to  the  liver  in  reverse  cholesterol  transport.Describe  how  the  liver  plays  a  central  role  in  lipid  transport  and  metabolism  and  how  hepatic  VLDL  secretion  is  regulated  by  the  diet  and  hormones.Indicate  the  roles  of  LDL  and  HDL  in  promoting  and  retarding,  respectively,  the  development  of  atherosclerosis.Indicate  the  causes  of  alcoholic  and  nonalcoholic  fatty  liver  disease  (NAFLD).Explain  the  processes  by  which  fatty  acids  are  released  from  triacylglycerol  stored  in  adipose  tissue.Understand  the  role  of  brown  adipose  tissue  in  the  generation  of  body  heat.