RT Book, Section
A1 Rodwell, Victor W.
A2 Rodwell, Victor W.
A2 Bender, David A.
A2 Botham, Kathleen M.
A2 Kennelly, Peter J.
A2 Weil, P. Anthony
SR Print(0)
ID 1160190015
T1 Biosynthesis of the Nutritionally Nonessential Amino Acids
T2 Harper's Illustrated Biochemistry, 31e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259837937
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160190015
RD 2024/04/25
AB OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Explain  why  the  absence  from  the  diet  of  certain  amino  acids  that  are  present  in  most  proteins  is  not  deleterious  to  human  health.Appreciate  the  distinction  between  the  terms  “essential”  and  “nutritionally  essential”  amino  acids,  and  identify  the  amino  acids  that  are  nutritionally  nonessential.Name  the  intermediates  of  the  citric  acid  cycle  and  of  glycolysis  that  are  precursors  of  aspartate,  asparagine,  glutamate,  glutamine,  glycine,  and  serine.Illustrate  the  key  role  of  transaminases  in  amino  acid  metabolism.Explain  the  process  by  which  the  4-hydroxyproline  and  5-hydroxylysine  of  proteins  such  as  collagen  are  formed.Describe  the  clinical  presentation  of  scurvy,  and  provide  a  biochemical  explanation  for  why  a  severe  deprivation  of  vitamin  C  (ascorbic  acid)  results  in  this  nutritional  disorder.Appreciate  that,  despite  the  toxicity  of  selenium,  selenocysteine  is  an  essential  component  of  several  mammalian  proteins.Define  and  outline  the  reaction  catalyzed  by  a  mixed-function  oxidase.Identify  the  role  of  tetrahydrobiopterin  in  tyrosine  biosynthesis.Indicate  the  role  of  a  modified  transfer  RNA  (tRNA)  in  the  cotranslational  insertion  of  selenocysteine  into  proteins.