RT Book, Section
A1 Rodwell, Victor W.
A2 Rodwell, Victor W.
A2 Bender, David A.
A2 Botham, Kathleen M.
A2 Kennelly, Peter J.
A2 Weil, P. Anthony
SR Print(0)
ID 1160190500
T1 Nucleotides
T2 Harper's Illustrated Biochemistry, 31e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259837937
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160190500
RD 2024/04/19
AB OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Write  structural  formulas  to  represent  the  amino-  and  oxo-tautomers  of  a  purine  and  of  a  pyrimidine  and  state  which  tautomer  predominates  under  physiologic  conditions.Reproduce  the  structural  formulas  for  the  principal  nucleotides  present  in  DNA  and  in  RNA  and  the  less  common  nucleotides  5-methylcytosine,  5-hydroxymethylcytosine,  and  pseudouridine  (ψ).Represent  D-ribose  or  2-deoxy-D-ribose  linked  as  either  a  syn  or  an  anti  conformer  to  a  purine,  name  the  bond  between  the  sugar  and  the  base,  and  indicate  which  conformer  predominates  under  most  physiologic  conditions.Number  the  C  and  N  atoms  of  a  pyrimidine  ribonucleoside  and  of  a  purine  deoxyribonucleoside,  including  using  a  primed  numeral  for  C  atoms  of  the  sugars.Compare  the  phosphoryl  group  transfer  potential  of  each  phosphoryl  group  of  a  nucleoside  triphosphate.Outline  the  physiologic  roles  of  the  cyclic  phosphodiesters  cAMP  and  cGMP.Appreciate  that  polynucleotides  are  directional  macromolecules  composed  of  mononucleotides  linked  by  3′  →  5′-phosphodiester  bonds.Be  familiar  with  the  abbreviated  representations  of  polynucleotide  structures  such  as  pTpGpT  or  TGCATCA,  for  which  the  5′-end  is  always  shown  at  the  left  and  all  phosphodiester  bonds  are  3′  →  5′.For  specific  synthetic  analogs  of  purine  and  pyrimidine  bases  and  their  derivatives  that  have  served  as  anticancer  drugs,  indicate  in  what  ways  these  compounds  inhibit  metabolism.