RT Book, Section
A1 Weil, P. Anthony
A2 Rodwell, Victor W.
A2 Bender, David A.
A2 Botham, Kathleen M.
A2 Kennelly, Peter J.
A2 Weil, P. Anthony
SR Print(0)
ID 1160191772
T1 Hormone Action & Signal Transduction
T2 Harper's Illustrated Biochemistry, 31e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259837937
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160191772
RD 2024/04/19
AB OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Explain  the  roles  of  stimulus,  hormone  release,  signal  generation,  and  effector  response  in  hormone-regulated  physiologic  processes.Describe  the  role  of  receptors  and  guanosine  nucleotide-binding  G-proteins  in  hormone  signal  transduction,  particularly  with  regard  to  the  generation  of  second  messengers.Appreciate  the  complex  patterns  of  signal  transduction  pathway  cross-talk  in  mediating  complicated  physiologic  outputs.Understand  the  key  roles  that  protein-ligand,  protein–protein,  protein  posttranslational  modification,  and  protein-DNA  interactions  play  in  mediating  hormone-directed  physiologic  processes.Detail  why  hormone-modulated  receptors,  second  messengers,  and  associated  signaling  molecules  represent  a  rich  source  of  potential  drug  target  development  given  their  key  roles  in  the  regulation  of  physiology.