RT Book, Section A1 Botham, Kathleen M. A1 Mayes, Peter A. A2 Rodwell, Victor W. A2 Bender, David A. A2 Botham, Kathleen M. A2 Kennelly, Peter J. A2 Weil, P. Anthony SR Print(0) ID 1163593486 T1 Biosynthesis of Fatty Acids & Eicosanoids T2 Harper's Illustrated Biochemistry, 31e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259837937 LK accesspharmacy.mhmedical.com/content.aspx?aid=1163593486 RD 2024/03/28 AB OBJECTIVESAfter studying this chapter, you should be able to:Describe the reaction catalyzed by acetyl-CoA carboxylase and understand the mechanisms by which its activity is regulated to control the rate of fatty acid synthesis.Outline the structure of the fatty acid synthase multienzyme complex, indicating the sequence of enzymes in the two peptide chains of the homodimer.Explain how long-chain fatty acids are synthesized by the repeated condensation of two carbon units, with formation of the 16-carbon palmitate being favored in most tissues, and identify the cofactors required.Indicate the sources of reducing equivalents (NADPH) for fatty acid synthesis.Explain how fatty acid synthesis is regulated by nutritional status and identify other control mechanisms that operate in addition to modulation of the activity of acetyl-CoA carboxylase.Identify the nutritionally essential fatty acids and explain why they cannot be formed in the body.Explain how polyunsaturated fatty acids are synthesized by desaturase and elongation enzymes.Outline the cyclooxygenase and lipoxygenase pathways responsible for the formation of the various classes of eicosanoids.