RT Book, Section
A1 Botham, Kathleen M.
A1 Mayes, Peter A.
A2 Rodwell, Victor W.
A2 Bender, David A.
A2 Botham, Kathleen M.
A2 Kennelly, Peter J.
A2 Weil, P. Anthony
SR Print(0)
ID 1160192627
T1 Metabolism of Acylglycerols & Sphingolipids
T2 Harper's Illustrated Biochemistry, 31e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259837937
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160192627
RD 2024/04/18
AB OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Explain  that  the  catabolism  of  triacylglycerols  involves  hydrolysis  to  free  fatty  acids  and  glycerol  and  indicate  the  fate  of  these  metabolites.Indicate  that  glycerol-3-phosphate  is  the  substrate  for  the  formation  of  both  triacylglycerols  and  phosphoglycerols  and  that  a  branch  point  at  phosphatidate  leads  to  the  synthesis  of  inositol  phospholipids  and  cardiolipin  or/and  triacylglycerols  and  other  phospholipids.Explain  that  plasmalogens  and  platelet-activating  factor  (PAF)  are  formed  by  a  complex  pathway  starting  from  dihydroxyacetone  phosphate.Illustrate  the  role  of  various  phospholipases  in  the  degradation  and  remodeling  of  phospholipids.Explain  that  ceramide  is  the  precursor  from  which  all  sphingolipids  are  formed.Indicate  how  sphingomyelin  and  glycosphingolipids  are  produced  by  the  reaction  of  ceramide  with  phosphatidylcholine  or  sugar  residue(s),  respectively.Identify  examples  of  disease  processes  caused  by  defects  in  phospholipid  or  sphingolipid  synthesis  or  breakdown.