RT Book, Section
A1 Botham, Kathleen M.
A1 Murray, Robert K.
A2 Rodwell, Victor W.
A2 Bender, David A.
A2 Botham, Kathleen M.
A2 Kennelly, Peter J.
A2 Weil, P. Anthony
SR Print(0)
ID 1160192994
T1 Intracellular Traffic & Sorting of Proteins
T2 Harper's Illustrated Biochemistry, 31e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259837937
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160192994
RD 2024/04/20
AB OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Indicate  that  many  proteins  are  targeted  by  signal  sequences  to  their  correct  destinations  and  that  the  Golgi  apparatus  plays  an  important  role  in  sorting  proteins.Recognize  that  specialized  signals  are  involved  in  sorting  proteins  to  mitochondria,  the  nucleus,  and  to  peroxisomes.Explain  that  N-terminal  signal  peptides  play  a  key  role  in  directing  newly  synthesized  proteins  into  the  lumen  of  the  endoplasmic  reticulum  (ER).Explain  how  chaperones  prevent  faulty  folding  of  other  proteins,  how  misfolded  proteins  are  disposed  of,  and  how  the  ER  acts  as  a  quality  control  compartment.Explain  the  role  of  ubiquitin  as  a  key  molecule  in  protein  degradation.Recognize  the  important  role  of  transport  vesicles  in  intracellular  transport.Indicate  that  many  diseases  result  from  mutations  in  genes  encoding  proteins  involved  in  intracellular  transport.