RT Book, Section
A1 Kennelly, Peter J.
A2 Rodwell, Victor W.
A2 Bender, David A.
A2 Botham, Kathleen M.
A2 Kennelly, Peter J.
A2 Weil, P. Anthony
SR Print(0)
ID 1160193930
T1 The Biochemistry of Aging
T2 Harper's Illustrated Biochemistry, 31e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259837937
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160193930
RD 2024/04/25
AB OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Describe  the  essential  features  of  wear  and  tear  theories  of  aging.List  four  or  more  common  environmental  constituents  known  to  damage  biologic  macromolecules  such  as  proteins  and  DNA.Explain  why  nucleotide  bases  are  especially  vulnerable  to  damage.Describe  the  most  physiologically  important  difference  between  mitochondrial  and  nuclear  genomes.Describe  the  oxidative  theory  of  aging.List  the  primary  sources  of  reactive  oxygen  species  (ROS)  in  humans.Describe  three  mechanisms  by  which  cells  prevent  or  repair  damage  inflicted  by  ROS.Describe  the  basic  tenets  of  metabolic  theories  of  aging.Explain  the  mechanism  of  the  telomere  “countdown  clock.”Outline  our  current  understanding  of  the  genetic  contribution  to  aging.Explain  the  benefits  of  model  organisms  to  biomedical  research.