RT Book, Section
A1 Konkle, Barbara A.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1160012761
T1 Disorders of Platelets and Vessel Wall
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160012761
RD 2024/04/18
AB Hemostasis  is  a  dynamic  process  in  which  the  platelet  and  the  blood  vessel  wall  play  key  roles.  Platelets  become  activated  upon  adhesion  to  von  Willebrand  factor  (VWF)  and  collagen  in  the  exposed  subendothelium  after  injury.  Platelet  activation  is  also  mediated  through  shear  forces  imposed  by  blood  flow  itself,  particularly  in  areas  where  the  vessel  wall  is  diseased,  and  is  also  affected  by  the  inflammatory  state  of  the  endothelium.  The  activated  platelet  surface  provides  the  major  physiologic  site  for  coagulation  factor  activation,  which  results  in  further  platelet  activation  and  fibrin  formation.  Genetic  and  acquired  influences  on  the  platelet  and  vessel  wall,  as  well  as  on  the  coagulation  and  fibrinolytic  systems,  determine  whether  normal  hemostasis  or  bleeding  or  clotting  symptoms  will  result.