RT Book, Section A1 Marrazzo, Jeanne M. A1 Holmes, King K. A2 Jameson, J. Larry A2 Fauci, Anthony S. A2 Kasper, Dennis L. A2 Hauser, Stephen L. A2 Longo, Dan L. A2 Loscalzo, Joseph SR Print(0) ID 1160012974 T1 Sexually Transmitted Infections: Overview and Clinical Approach T2 Harrison's Principles of Internal Medicine, 20e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259644016 LK accesspharmacy.mhmedical.com/content.aspx?aid=1160012974 RD 2024/03/28 AB Worldwide, most adults acquire at least one sexually transmitted infection (STI), and many remain at risk for complications. Each day, for example, more than 1 million STIs are acquired worldwide, placing many affected persons at risk for adverse reproductive health outcomes and neoplasia. Certain STIs, such as syphilis, gonorrhea, HIV infection, hepatitis B, and chancroid, often occur in highly interconnected sexual networks characterized by high rates of partner change or multiple concurrent partners. Such networks, for example, often include persons who engage in transactional sex, men who have sex with men (MSM), and persons involved in the use of illicit drugs, particularly methamphetamine. Other STIs are distributed more evenly throughout populations. For example, chlamydial infections, genital human papillomavirus (HPV) infections, and genital herpes can spread efficiently even in relatively low-risk populations. Finally, modern technologies based on detection of nucleic acid have accelerated elucidation of the role of sexual transmission in the spread of some viruses, including Ebola virus and Zika virus, and have provided new evidence of apparent sexual transmission of several bacteria, including group C Neisseria meningitidis and anaerobes associated with bacterial vaginosis (BV).