RT Book, Section
A1 Casadevall, Arturo
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1155971238
T1 Cryptococcosis
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accesspharmacy.mhmedical.com/content.aspx?aid=1155971238
RD 2024/04/19
AB Cryptococcus,  a  genus  of  yeast-like  fungi,  is  the  etiologic  agent  of  cryptococcosis.  Until  recently,  cryptococcal  strains  were  separated  into  two  species,  Cryptococcus  neoformans  and  Cryptococcus  gattii,  both  of  which  can  cause  cryptococcosis  in  humans.  The  two  varieties  of  C.  neoformans—grubii  and  neoformans—correlate  with  serotypes  A  and  D,  respectively.  C.  gattii,  although  not  divided  into  varieties,  also  is  antigenically  diverse,  encompassing  serotypes  B  and  C.  However,  genome  sequencing  studies  have  now  revealed  tremendous  diversity  among  isolates  previously  assigned  to  each  species,  suggesting  that  some  may  be  reclassified  as  new  species.  Most  clinical  microbiology  laboratories  do  not  routinely  distinguish  between  C.  neoformans  and  C.  gattii  or  among  varieties,  but  rather  identify  and  report  all  isolates  simply  as  C.  neoformans.