RT Book, Section
A1 Faxon, David P.
A1 Bhatt, Deepak L.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1155975049
T1 Percutaneous Coronary Interventions and Other Interventional Procedures
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accesspharmacy.mhmedical.com/content.aspx?aid=1155975049
RD 2024/04/17
AB Percutaneous  transluminal  coronary  angioplasty  (PTCA)  was  first  introduced  by  Andreas  Gruentzig  in  1977  as  an  alternative  to  coronary  bypass  surgery.  The  concept  was  initially  demonstrated  by  Charles  Dotter  in  1964  in  peripheral  vessels.  The  development  of  a  small  inelastic  balloon  catheter  by  Gruentzig  allowed  expansion  of  the  technique  into  smaller  peripheral  and  coronary  vessels.  Initial  coronary  experience  was  limited  to  single-vessel  coronary  disease  and  discrete  proximal  lesions  due  to  the  technical  limitations  of  the  equipment.  Advances  in  technology  and  greater  operator  experience  allowed  the  procedure  to  grow  rapidly  with  expanded  use  in  patients  with  more  complex  lesions  and  multivessel  disease.  The  introduction  of  coronary  stents  in  1994  was  one  of  the  major  advances  in  the  field.  These  devices  reduced  acute  complications  and  reduced  by  half  the  significant  problems  of  acute  thrombosis  and  late  restenosis  (or  recurrence  of  the  stenosis).  Further  reductions  in  restenosis  were  achieved  by  the  introduction  of  drug-eluting  stents  in  2003.  These  stents  slowly  release  antiproliferative  drugs  directly  into  the  plaque  over  a  few  months.  Percutaneous  coronary  intervention  (PCI)  is  the  most  common  revascularization  procedure  in  the  United  States  and  is  performed  more  than  twice  as  often  as  coronary  artery  bypass  surgery:  nearly  900,000  patients  a  year.