RT Book, Section A1 Hemphill, III, J. Claude A1 Smith, Wade S. A1 Josephson, S. Andrew A1 Gress, Daryl R. A2 Jameson, J. Larry A2 Fauci, Anthony S. A2 Kasper, Dennis L. A2 Hauser, Stephen L. A2 Longo, Dan L. A2 Loscalzo, Joseph SR Print(0) ID 1181485903 T1 Severe Acute Encephalopathies and Critical Care Weakness T2 Harrison's Principles of Internal Medicine, 20e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259644016 LK accesspharmacy.mhmedical.com/content.aspx?aid=1181485903 RD 2024/03/28 AB Life-threatening neurologic illness may be caused by a primary disorder affecting any region of the neuraxis or may occur as a consequence of a systemic disorder such as hepatic failure, multisystem organ failure, or cardiac arrest (Table 301-1). Neurologic critical care focuses on preservation of neurologic tissue and prevention of secondary brain injury caused by ischemia, hemorrhage, edema, herniation, and elevated intracranial pressure (ICP). Encephalopathy is a general term describing brain dysfunction that is diffuse, global, or multi-focal. Severe acute encephalopathies represent a group of various disorders due to different neurological or systemic etiologies, but that share the common themes of primary and secondary brain injury.