RT Book, Section
A1 Lewis, Julia B.
A1 Neilson, Eric G.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1156520317
T1 Glomerular Diseases
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accesspharmacy.mhmedical.com/content.aspx?aid=1156520317
RD 2024/04/16
AB Two  human  kidneys  harbor  nearly  1.8  million  glomerular  capillary  tufts.  Each  glomerular  tuft  resides  within  Bowman’s  space.  The  capsule  circumscribing  this  space  is  lined  by  parietal  epithelial  cells  that  transition  into  tubular  epithelia  forming  the  proximal  nephron  or  migrate  into  the  tuft  to  replenish  podocytes.  The  glomerular  capillary  tuft  derives  from  an  afferent  arteriole  that  forms  a  branching  capillary  bed  embedded  in  mesangial  matrix  (Fig.  308-1).  This  capillary  network  funnels  into  an  efferent  arteriole,  which  passes  filtered  blood  into  cortical  peritubular  capillaries  or  medullary  vasa  recta  that  supply  and  exchange  with  a  folded  tubular  architecture.  Hence  the  glomerular  capillary  tuft,  fed  and  drained  by  arterioles,  represents  an  arteriolar  portal  system.  Fenestrated  endothelial  cells  resting  on  a  glomerular  basement  membrane  (GBM)  line  glomerular  capillaries.  Delicate  foot  processes  extending  from  epithelial  podocytes  shroud  the  outer  surface  of  these  capillaries,  and  adjacent  podocytes  interconnect  to  each  other  by  slit-pore  membranes  forming  a  selective  filtration  barrier.