RT Book, Section
A1 Seifter, Julian L.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1183265968
T1 Urinary Tract Obstruction
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accesspharmacy.mhmedical.com/content.aspx?aid=1183265968
RD 2023/03/21
AB Obstruction  to  the  flow  of  urine,  with  attendant  stasis  and  elevation  in  urinary  tract  pressure,  impairs  renal  and  urinary  conduit  functions  and  is  a  common  cause  of  acute  and  chronic  kidney  disease  (obstructive  nephropathy).  Early  recognition  and  prompt  treatment  of  urinary  tract  obstruction  (UTO)  can  prevent  or  reverse  devastating  effects  on  kidney  structure  and  function,  and  decrease  susceptibility  to  hypertension,  infection,  and  stone  formation.  Chronic  obstruction  may  lead  to  permanent  loss  of  renal  mass  (renal  atrophy)  and  excretory  capability.  Since  obstructive  disease  may  be  secondary  to  serious  underlying  inflammatory,  vascular,  or  malignant  disease,  familiarity  with  clinical  findings,  appropriate  diagnostic  testing,  and  therapeutic  approach  is  of  great  importance  to  the  clinician.