RT Book, Section
A1 Favus, Murray J.
A1 Vokes, Tamara J.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1160017615
T1 Paget’s Disease and Other Dysplasias of Bone
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160017615
RD 2024/04/20
AB Paget’s  disease  is  a  localized  bone-remodeling  disorder  that  affects  widespread,  noncontiguous  areas  of  the  skeleton.  The  pathologic  process  is  initiated  by  overactive  osteoclastic  bone  resorption  followed  by  a  compensatory  increase  in  osteoblastic  new  bone  formation,  resulting  in  a  structurally  disorganized  mosaic  of  woven  and  lamellar  bone.  Pagetic  bone  is  expanded,  less  compact,  and  more  vascular;  thus,  it  is  more  susceptible  to  deformities  and  fractures.  Although  most  patients  are  asymptomatic,  symptoms  resulting  directly  from  bony  involvement  (bone  pain,  secondary  arthritis,  fractures)  or  secondarily  from  the  expansion  of  bone  causing  compression  of  surrounding  neural  tissue  are  not  uncommon.