RT Book, Section A1 Katzung, Bertram G. A1 Kruidering-Hall, Marieke A1 Trevor, Anthony J. SR Print(0) ID 1156529169 T1 Antidepressants T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 12e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259641022 LK accesspharmacy.mhmedical.com/content.aspx?aid=1156529169 RD 2024/04/18 AB Major depressive disorder (MDD), or endogenous depression, is a depression of mood without any obvious medical or situational causes, manifested by an inability to cope with ordinary events or experience pleasure. The drugs used in MDD are of varied chemical structures; many have effects that enhance the CNS actions of norepinephrine, serotonin, or both.