RT Book, Section A1 Esfandiari, Nazanene H. A1 McPhee, Stephen J. A2 Hammer, Gary D. A2 McPhee, Stephen J. SR Print(0) ID 1156659974 T1 Thyroid Disease T2 Pathophysiology of Disease: An Introduction to Clinical Medicine, 8e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781260026504 LK accesspharmacy.mhmedical.com/content.aspx?aid=1156659974 RD 2024/03/28 AB The thyroid gland synthesizes the hormones thyroxine (T4) (prohormone) and triiodothyronine (T3) (active hormone), iodine-containing amino acids that regulate the body’s metabolic rate. Adequate levels of thyroid hormone are necessary in infants for normal central nervous system (CNS) development, in children for normal skeletal growth and maturation, and in adults for the normal function of multiple organ systems. Thyroid dysfunction is one of the most common endocrine disorders encountered in clinical practice. Although abnormally high or low levels of thyroid hormones may be tolerated for long periods of time, there are usually symptoms and signs of overt thyroid dysfunction.