RT Book, Section A1 Reed, Brent N. A1 Rodgers, Jo E. A2 Sutton, S. Scott SR Print(0) ID 1158313208 T1 Chronic Heart Failure T2 McGraw-Hill's NAPLEX® Review Guide, 3e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781260135923 LK accesspharmacy.mhmedical.com/content.aspx?aid=1158313208 RD 2024/04/18 AB Heart failure (HF) is a syndrome of reduced cardiac output (CO) resulting from impaired ventricular ejection, impaired filling, or components of both. HF with reduced ejection fraction (HFrEF) was formerly known as systolic dysfunction whereas HF with impaired filling or HF with preserved ejection fraction (HFpEF) was formerly known as diastolic dysfunction. Although half of HF cases are due to HFpEF, the majority of studies enrolled patients with HFrEF. Chronic HFrEF management includes lifestyle modifications, medications, and implantable devices. However, there are few therapeutic approaches for HFpEF management.