RT Book, Section A1 Sutton, S. Scott A1 Bland, Christopher M. A1 Quidley, April M. A1 Dunn, Brianne L. A1 Branan, Trisha N. A2 Sutton, S. Scott SR Print(0) ID 1158314557 T1 Sepsis Syndromes T2 McGraw-Hill's NAPLEX® Review Guide, 3e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781260135923 LK accesspharmacy.mhmedical.com/content.aspx?aid=1158314557 RD 2024/03/29 AB Sepsis is a continuum of physiologic stages characterized by infection, systemic inflammation, and hypoperfusion leading to tissue injury and organ failure (Table 26-1 for definitions to utilize for sepsis syndromes). Risk factors for sepsis include extremes of age, cancer, immunodeficiency, chronic organ failure, genetic factors (male and non-white ethnic origin in North America), patients with bacteremia, and genetic polymorphisms associated with immune regulation. Pulmonary, gastrointestinal, genitourinary, and bloodstream infections account for the majority of sepsis cases.