RT Book, Section
A1 Branan, Trisha N.
A1 Hawkins, W. Anthony
A2 Sutton, S. Scott
SR Print(0)
ID 1158314956
T1 Acute Kidney Injury
T2 McGraw-Hill's NAPLEX® Review Guide, 3e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781260135923
LK accesspharmacy.mhmedical.com/content.aspx?aid=1158314956
RD 2024/04/20
AB Acute  kidney  injury  (AKI)  occurs  when  there  is  a  sudden  and  significant  decrease  in  kidney  function.  An  increase  in  the  serum  creatinine  (SCr)  concentration  is  the  result  of  accumulation  due  to  a  decrease  in  the  glomerular  filtration  rate  (GFR).  The  diagnosis  of  AKI  is  based  on  the  change  in  SCr  from  baseline  and/or  changes  in  urinary  output  (UOP).  AKI  can  occur  because  the  kidneys  are  vulnerable  to  certain  types  of  injury.  First,  they  are  dependent  upon  the  heart  and  vasculature  to  deliver  sufficient  blood  supply  to  drive  glomerular  filtration.  Second,  they  are  exposed  to  numerous  endogenous  and  exogenous  substances,  which  are  eliminated  from  the  body  via  the  urine.