RT Book, Section
A1 Krishnan, Kannan
A2 Klaassen, Curtis D.
SR Print(0)
ID 1158497449
T1 Toxicokinetics
T2 Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th edition
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259863745
LK accesspharmacy.mhmedical.com/content.aspx?aid=1158497449
RD 2024/04/19
AB Toxicokinetics  refers  to  the  quantitative  study  of  absorption,  distribution,  metabolism,  and  excretion  (ADME)  of  chemicals  in  biota  through  measurement  and  modeling  of  their  concentrations  or  amounts  in  biological  matrices  (e.g.,  blood,  plasma,  excreta,  exhaled  air,  tissues)  as  a  function  of  time.  Experimental  studies  of  toxicokinetics  facilitate  the  characterization  of  the  temporal  profile  of  the  concentration  of  chemicals  and  their  metabolites  in  the  target  tissue  or  other  biological  matrices,  reflective  of  the  net  effect  of  the  rate  and  extent  of  absorption  through  one  or  more  exposure  routes,  distribution  to  tissues  and  organs  via  systemic  circulation  as  well  as  disposition  by  metabolism  and  excretion  (Fig.  7-1).  The  experimental  and  quantitative  approaches  used  today  for  characterizing  toxicokinetics  of  xenobiotics  were  derived  from  such  studies  extensively  conducted  with  drugs  over  the  past  decades  (traditionally  known  as  pharmacokinetics)  (Gibaldi  and  Perrier,  1975,  1982;  O'Flaherty,  1981;  WHO,  1986;  Rescigno,  1997;  Tozer  and  Rowland,  2006).  Toxicokinetic  data  and  analyses  constitute  an  essential  part  of  systematic  approaches  to  safety/risk  evaluation  of  xenobiotics  and  other  substances  including  therapeutic  drugs.