RT Book, Section
A1 Klaunig, James E.
A1 Wang, Zemin
A2 Klaassen, Curtis D.
SR Print(0)
ID 1158497752
T1 Chemical Carcinogenesis
T2 Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th edition
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259863745
LK accesspharmacy.mhmedical.com/content.aspx?aid=1158497752
RD 2024/04/20
AB Cancer  is  a  disease  characterized  by  genomic  mutation,  modified  gene  expression,  cell  proliferation,  and  aberrant  cell  growth.  It  ranks  as  one  of  the  leading  causes  of  death  in  the  world.  In  the  United  States,  cancer  ranks  as  the  second  leading  cause  of  death,  with  over  1.68  million  new  cases  of  cancer  diagnosed  and  more  than  0.6  million  Americans  dying  from  cancer  annually  (Siegel  et  al.,  2016).  Multiple  causes  of  cancer  have  been  established  including  infectious  agents,  radiation,  and  chemicals.  Estimates  suggest  that  70%  to  90%  of  all  human  cancers  have  a  linkage  to  environmental,  dietary,  and  behavioral  factors  (Fig.  8-1).  Although  our  understanding  of  the  biology  of  the  progression  from  a  normal  cell  to  a  malignant  one  has  advanced  considerably  in  the  past  several  decades,  many  aspects  of  the  cause,  prevention,  and  treatment  of  human  cancer  and  in  particular  the  influence  of  lifestyle  remain  to  be  completely  resolved.