RT Book, Section
A1 Kaplan, Barbara L.F.
A1 Sulentic, Courtney E.W.
A1 Haggerty, Helen G.
A1 Holsapple, Michael P.
A1 Kaminski, Norbert E.
A2 Klaassen, Curtis D.
SR Print(0)
ID 1158498988
T1 Toxic Responses of the Immune System
T2 Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th edition
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259863745
LK accesspharmacy.mhmedical.com/content.aspx?aid=1158498988
RD 2024/04/25
AB Immunotoxicology  can  be  most  simply  defined  as  the  study  of  adverse  effects  on  the  immune  system  resulting  from  occupational,  inadvertent,  or  therapeutic  exposure  to  drugs,  environmental  chemicals,  and,  in  some  instances,  biological  materials.  Studies  in  animals  and  humans  have  indicated  that  the  immune  system  is  comprised  of  potential  target  organs,  and  that  damage  to  this  system  can  be  associated  with  morbidity  and  even  mortality.  Indeed,  in  some  instances,  the  immune  system  can  be  compromised  (decreased  lymphoid  cellularity,  alterations  in  lymphocyte  subpopulations,  decreased  host  resistance,  altered  specific  immune  function  responses)  in  the  absence  of  observed  toxicity  in  other  organ  systems.  These  studies  coupled  with  tremendous  advances  made  in  immunology  and  molecular  biology  have  led  to  a  steady  and  exponential  growth  in  our  understanding  of  immunotoxicology  during  the  past  40  years.  Recognition  by  regulatory  agencies  that  the  immune  system  is  an  important,  as  well  as  sensitive,  target  organ  for  chemical-  and  drug-induced  toxicity  is  another  indication  of  the  growth  of  this  subdiscipline  of  toxicology.  With  the  availability  of  sensitive,  reproducible,  and  predictive  tests,  it  is  now  apparent  that  the  inclusion  of  immunotoxicity  testing  represents  a  significant  adjunct  to  routine  safety  evaluations  for  therapeutics,  biologics,  and  chemicals  now  in  development.