RT Book, Section
A1 Warheit, David B.
A1 Oberdörster, Günter
A1 Kane, Agnes B.
A1 Brown, Scott C.
A1 Klaper, Rebecca D.
A1 Hurt, Robert H.
A2 Klaassen, Curtis D.
SR Print(0)
ID 1158503619
T1 Nanoparticle Toxicology
T2 Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th edition
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259863745
LK accesspharmacy.mhmedical.com/content.aspx?aid=1158503619
RD 2024/04/24
AB Since  the  classic  talk  by  Richard  Feynman  (1960)  entitled  “There  Is  Plenty  of  Room  at  the  Bottom,”  nanotechnology  has  grown  to  a  multibillion  dollar  industry  worldwide,  with  1300  nanotechnology-enabled  products  in  commercial  use  by  2010  (Woodrow  Wilson  Center,  2012).  The  potential  of  adverse  effects  from  exposure  to  “nanophase  materials”  was  already  pointed  out  earlier  (Oberdörster  and  Ferin,  1992;  Oberdörster  et  al.,  1992),  and  concerns  about  human  and  environmental  health  and  safety  of  engineered  nanomaterials  (ENMs)  were  initially  raised  in  2003  (Colvin,  2003).  Since  then,  toxicity  of  high  volume,  commercial  nanomaterials  including  nanosilver,  fullerenes,  quantum  dots,  carbon  nanotubes  (CNTs),  graphene-based  materials,  and  metal  oxide  nanoparticles  (NPs)  has  been  summarized  in  several  reviews  (Donaldson  et  al.,  2004;  Borm  et  al.,  2006;  Nel  et  al.,  2006;  Boczkowski  and  Hoet,  2009;  Krug  and  Wick,  2011;  Kunzmann  et  al.,  2011;  Sanchez  et  al.,  2012).  New  ENMs  and  composites  are  continually  emerging  with  potential  for  significant  commercial  applications  in  energy  generation,  environmental  sensing  and  remediation,  aerospace  and  defense,  and  medical  diagnosis  and  therapy.  Examples  of  nanoscale  materials  of  different  shapes  and  sizes  are  depicted  in  Fig.  29-1.  Investigations  of  the  magnitude  of  release  of  manufactured  nanomaterials  and  their  subsequent  fate,  transport,  transformation,  and  potential  for  human  and  environmental  exposure  and  toxicity  (Fig.  29-2)  have  been  areas  of  active  research  (Mueller  and  Nowack,  2008;  Krug,  2014).