RT Book, Section A1 Gold, Jeffrey A. A1 Nelson, Lewis S. A2 Nelson, Lewis S. A2 Howland, Mary Ann A2 Lewin, Neal A. A2 Smith, Silas W. A2 Goldfrank, Lewis R. A2 Hoffman, Robert S. SR Print(0) ID 1163018399 T1 Alcohol Withdrawal T2 Goldfrank's Toxicologic Emergencies, 11e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259859618 LK accesspharmacy.mhmedical.com/content.aspx?aid=1163018399 RD 2024/04/19 AB The medical problems associated with alcoholism and alcohol withdrawal were initially described by Pliny the Elder in the first century B.C. In his work Naturalis Historia, the alcoholic and alcohol withdrawal were described as follows: “drunkenness brings pallor and sagging cheeks, sore eyes, and trembling hands that spill a full cup, of which the immediate punishment is a haunted sleep and unrestful nights.”74 Initial treatments as described by Osler at the turn of the 20th century were focused on supportive care, including confinement to bed, cold baths to reduce fever, and judicious use of potassium bromide, chloral hydrate, hyoscine, and possibly opium.18