RT Book, Section
A1 Holubek, William J.
A2 Nelson, Lewis S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Smith, Silas W.
A2 Goldfrank, Lewis R.
A2 Hoffman, Robert S.
SR Print(0)
ID 1163010252
T1 Nonsteroidal Antiinflammatory Drugs
T2 Goldfrank's Toxicologic Emergencies, 11e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259859618
LK accesspharmacy.mhmedical.com/content.aspx?aid=1163010252
RD 2024/04/18
AB In  the  1950s,  the  only  treatment  for  rheumatoid  arthritis  included  high-dose  aspirin  and  gold  therapy  (chrysotherapy).  While  searching  for  new  compounds  that  were  chemically  nonsteroidal  and  had  antiinflammatory  properties,  Dr.  Stewart  Adams  filed  a  patent  for  “Antiinflammatory  Agents”  in  1961.  One  of  the  compounds  in  this  list  was  2-(4-isobutylphenyl)  propionic  acid,  which  today  we  call  ibuprofen.  This  discovery  created  a  new  class  of  drugs  designated  as  nonsteroidal  antiinflammatory  drugs  (NSAIDs).36  Ibuprofen  was  initially  marketed  in  the  United  Kingdom  in  1969  and  was  introduced  to  the  US  market  in  1974.  Ibuprofen  became  available  without  a  prescription  in  the  United  States  in  1984.