RT Book, Section A1 Riedel, Stefan A1 Hobden, Jeffery A. A1 Miller, Steve A1 Morse, Stephen A. A1 Mietzner, Timothy A. A1 Detrick, Barbara A1 Mitchell, Thomas G. A1 Sakanari, Judy A. A1 Hotez, Peter A1 Mejia, Rojelio SR Print(0) ID 1163283441 T1 Orthomyxoviruses (Influenza Viruses) T2 Jawetz, Melnick, & Adelberg's Medical Microbiology, 28e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781260012026 LK accesspharmacy.mhmedical.com/content.aspx?aid=1163283441 RD 2024/04/19 AB Respiratory illnesses are responsible for more than half of all acute illnesses each year in the United States. The Orthomyxoviridae (influenza viruses) are a major determinant of morbidity and mortality caused by respiratory disease, and outbreaks of infection sometimes occur in worldwide epidemics. Influenza has been responsible for millions of deaths worldwide. Mutability and high frequency of genetic reassortment and resultant antigenic changes in the viral surface glycoproteins make influenza viruses formidable challenges for control efforts. Influenza type A is antigenically highly variable and is responsible for most cases of epidemic influenza. Influenza type B may exhibit antigenic changes and sometimes causes epidemics. Influenza type C is antigenically stable and causes only mild illness in immunocompetent individuals.