RT Book, Section A1 Mobley, W. Cary A2 Mobley, W. Cary A2 Amiji, Mansoor M. A2 Cook, Thomas J. SR Print(0) ID 1163539768 T1 Introduction to Biopharmaceutics T2 Applied Physical Pharmacy, 3e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781260452211 LK accesspharmacy.mhmedical.com/content.aspx?aid=1163539768 RD 2024/03/28 AB Learning ObjectivesAfter completing this chapter, the reader should be able to:List the types and locations of drug targets.List common dosage forms and the nature of the drug within the listed dosage forms.Describe common routes of drug administration, including the administration locations and the absorption sites.Define bioavailability and describe important physiological and physicochemical factors that influence a drug's bioavailability.Describe the following physicochemical factors that can influence the fate of the drug in the body: solid state properties, ionization, solubility and dissolution, partition coefficient, mass transport and membrane passage, complexation, and protein binding.Briefly describe each parameter in the LADME acronym.Describe the general roles of drug transporters (with examples) in the ADME processes of a drug's disposition in the body.Describe, in general, how drugs are liberated from their dosage forms.Describe gastrointestinal drug absorption into the systemic circulation, including the influences of a drug's physicochemical properties, and the steps taken by a dissolved drug in the small intestines to its entry into enterocytes, hepatocytes, and finally the bloodstream.Describe enterohepatic cycling, possible rate-limiting steps in drug absorption, and first-pass metabolism.Describe the distribution of a drug from the plasma to the interstitia of tissues, including the influences of a drug's physicochemical properties, and of binding to plasma proteins and to tissue components.List other distribution sites, including the CNS, fat, and placenta.Define the apparent volume of drug distribution and relate it to the distribution of body water.Give an overview of the necessity, phases, and locations of drug metabolism.Describe renal drug excretion, including the influences of a drug's physicochemical properties.List nonrenal excretory pathways.Define and describe clearance and half-life, and briefly relate them to their importance for drug dosing.