RT Book, Section
A1 Sandmann, Beverly J.
A1 Amiji, Mansoor M.
A2 Mobley, W. Cary
A2 Amiji, Mansoor M.
A2 Cook, Thomas J.
SR Print(0)
ID 1163540490
T1 Solubility, Dissolution, and Partitioning
T2 Applied Physical Pharmacy, 3e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781260452211
LK accesspharmacy.mhmedical.com/content.aspx?aid=1163540490
RD 2024/04/20
AB Learning  ObjectivesAfter  completing  this  chapter,  the  reader  should  be  able  to:Define  and  understand  the  terms  and  concepts  of  solubility  and  miscibility.Identify  the  descriptive  terms  for  solubility,  their  meaning,  and  their  percent  value.Recognize  factors  that  affect  solubility.Calculate  the  solubility  of  poorly  soluble  strong  electrolytes  by  using  Ksp  values.Calculate  the  solubility  of  weak  electrolytes  as  a  function  of  pH  and  understand  what  the  answer  means.Calculate  the  pH  of  precipitation  for  weak  electrolytes  in  aqueous  and  mixed  solvent  systems.Describe  the  role  of  drug  dissolution  from  dosage  forms  in  drug  bioavailability.Relate  the  parameters  of  the  Noyes–Whitney  equation  to  the  variables  that  affect  the  dissolution  rate  of  drug  particles.Recognize  and  appreciate  the  United  States  Pharmacopeia  (USP)  requirements  for  dissolution  studies.Discuss  how  various  physicochemical,  formulation,  and  physiological  factors  can  influence  dissolution  behavior.Define  and  understand  the  partitioning  law,  partition  coefficients,  and  apparent  partition  coefficients.Calculate  the  partition  coefficients  for  different  types  of  solutes  in  aqueous/organic  solvent  systems.Determine  the  effect  of  pH  on  the  partition  coefficient  of  weak  electrolytes  and  on  their  excretion  in  different  body  fluids.