RT Book, Section
A1 Amiji, Mansoor M.
A2 Mobley, W. Cary
A2 Amiji, Mansoor M.
A2 Cook, Thomas J.
SR Print(0)
ID 1163540775
T1 Complexation and Protein Binding
T2 Applied Physical Pharmacy, 3e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781260452211
LK accesspharmacy.mhmedical.com/content.aspx?aid=1163540775
RD 2024/04/18
AB Learning  ObjectivesAfter  completing  this  chapter,  the  reader  should  be  able  to:Understand  the  significance  of  complexation  in  pharmaceutical  products.Appreciate  the  fundamental  forces  that  are  related  to  the  formation  of  drug  complexes.Differentiate  between  coordination  and  molecular  complexation.Understand  the  mechanism  of  coordinate  bond  formation  leading  to  the  formation  of  coordinate  complexes.Appreciate  the  biological  and  pharmaceutical  roles  of  coordinate  complexes.Describe  the  mechanism  of  inclusion  complex  formation,  with  special  emphasis  on  drug–cyclodextrin  complexes.Relate  the  formation  of  drug–cyclodextrin  complexes  with  improvements  in  the  physicochemical  properties  and  bioavailability  of  drugs.Determine  the  values  of  the  association  constant  and  the  stoichiometry  of  association.Understand  the  importance  of  the  ion-exchange  mechanism  and  its  role  in  drug  delivery  and  therapy.Appreciate  the  significance  of  protein–ligand  interactions.Understand  the  significance  of  plasma  protein  binding  for  the  distributive  properties  of  drugs  in  the  body.Identify  the  important  properties  of  plasma  proteins  and  the  mechanism  of  their  interactions  with  drugs.Appreciate  equilibrium  dialysis  and  other  techniques  for  in  vitro  analysis  of  drug–protein  binding.Analyze  protein-binding  data  by  the  double-reciprocal  method  and  determine  the  values  of  the  association  constant  and  the  number  of  binding  sites.Analyze  protein-binding  data  by  the  Scatchard  method  and  determine  the  values  of  the  association  constant  and  the  number  of  binding  sites.Appreciate  the  advantages  of  the  Scatchard  method  over  the  double-reciprocal  method  of  analysis  with  respect  to  multiple  binding  affinities.