RT Book, Section
A1 Cook, Thomas J.
A2 Mobley, W. Cary
A2 Amiji, Mansoor M.
A2 Cook, Thomas J.
SR Print(0)
ID 1163541445
T1 Chemical Kinetics of Pharmaceuticals
T2 Applied Physical Pharmacy, 3e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781260452211
LK accesspharmacy.mhmedical.com/content.aspx?aid=1163541445
RD 2021/02/27
AB Learning ObjectivesAfter completing this chapter, the reader should be able to:Describe the impact of reaction kinetics in the context of drug formulations.Describe the impact of reaction kinetics in the context of pharmacotherapy.Indicate the units of the reaction rate constants for zero-order and first-order reactions.For zero-order and first-order reactions, define the rate equations, the integrated rate equations, and the mathematical expressions for half-life (tÂ½) and shelf-life (t90).Describe the concept of pseudo reaction order.From tabulated reaction kinetic data, create a graph of drug concentration versus time and use the graph to determine the rate constants, half-life, and shelf-life values, and apparent reaction order.Calculate the shelf-life (t90) of drugs from mathematical equations and from graphical representations of reaction kinetic data.Describe the influence of temperature on reaction rates.Estimate the shelf-life (t90) and expiration time of drugs at storage temperature by analyzing accelerated stability-testing data.Describe the impact of pH and solvent on the catalysis of reactions.Evaluate the log k versus pH profile of drugs and identify the pH at which a drug is most stable.Apply first-order reaction rate concepts to complex reactions such as reversible, parallel, and consecutive (series) reactions.Relate reaction kinetic principles to pharmacokinetics.