RT Book, Section A1 Murri, Nelda A2 Brunton, Laurence L. A2 Hilal-Dandan, Randa A2 Knollmann, Björn C. SR Print(0) ID 1175037358 T1 Goodman & Gilman Year in Review New and Noteworthy FDA Approvals T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259584732 LK accesspharmacy.mhmedical.com/content.aspx?aid=1175037358 RD 2024/03/28 AB AbbreviationsAAV: adeno-associated virusaTTP: acquired thrombotic thrombocytopenic purpuraADC: antibody–drug conjugateASO: antisense oligonucleotideATTR: transthyretin amyloidosisATTR-CM: transthyretin amyloid cardiomyopathyBCRP: breast cancer–resistant proteinBLAs: biologic license applicationsCAR: chimeric antigen receptorFDA: U.S. Food and Drug AdministrationFGFR: fibroblast growth factorGST: glutathione S transferasehATTR-PM: polyneuropathy manifestations of hereditary ATTRHRSA: Health Resources and Services AdministrationHSDD: hypoactive sexual desire disorderLRP: lipoprotein-related proteinMCR: melanocortin receptorMMAE: monomethyl auristatin E (vedotin)NDA: new drug applicationNES: nuclear export signalOA: onasemnogene abeparvovecPV: polatuzumab vedotinscAAV9: self-complementary AAV serotype 9sd: single-domainsdAb: single-domain antibody fragmentsSINE: selective inhibitor of nuclear exportsiRNA: small interfering double-stranded ribonucleic acidSMA: spinal muscular atrophySMN: survival motor neuronTTR: transthyretinUGT: UDP–glucuronosyltransferasevWF: von Willebrand factorWnt: wingless-type mouse mammary virus integration siteXPO1: exportin 1