RT Book, Section
A1 Cavallari, Larisa H.
A1 Lam, Y. W. Francis
A2 DiPiro, Joseph T.
A2 Yee, Gary C.
A2 Posey, L. Michael
A2 Haines, Stuart T.
A2 Nolin, Thomas D.
A2 Ellingrod, Vicki
SR Print(0)
ID 1182422910
T1 Pharmacogenetics
T2 Pharmacotherapy: A Pathophysiologic Approach, 11e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260116816
LK accesspharmacy.mhmedical.com/content.aspx?aid=1182422910
RD 2024/04/19
AB KEY  CONCEPTS  Genetic  variation  contributes  to  pharmacokinetic  and  pharmacodynamic  drug  properties.  Genetic  variation  occurs  for  drug  metabolism,  drug  transporter,  and  drug  target  proteins,  as  well  as  disease-associated  proteins  that  may  impact  drug  response.  Single-nucleotide  polymorphisms  are  the  most  common  gene  variations  associated  with  drug  response.  Genetic  polymorphisms  may  influence  drug  effectiveness  and  risk  for  toxicity.  Pharmacogenetics  is  the  study  of  the  impact  of  genetic  polymorphisms  on  drug  response.  The  goals  of  pharmacogenetics  are  to  optimize  drug  efficacy  and  limit  drug  toxicity  based  on  an  individual’s  DNA.  Gene  therapy  aims  to  cure  disease  caused  by  genetic  defects  by  changing  gene  expression.  Inadequate  gene  delivery  and  expression  and  serious  adverse  effects  are  obstacles  to  successful  gene  therapy.