RT Book, Section
A1 Nahata, Milap C.
A1 Taketomo, Carol
A2 DiPiro, Joseph T.
A2 Yee, Gary C.
A2 Posey, L. Michael
A2 Haines, Stuart T.
A2 Nolin, Thomas D.
A2 Ellingrod, Vicki
SR Print(0)
ID 1182426938
T1 Pediatrics: General Topics in Pediatric Pharmacotherapy
T2 Pharmacotherapy: A Pathophysiologic Approach, 11e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260116816
LK accesspharmacy.mhmedical.com/content.aspx?aid=1182426938
RD 2024/04/19
AB KEY  CONCEPTS  Children  are  not  just  “little  adults,”  and  lack  of  data  on  important  pharmacokinetic  and  pharmacodynamic  differences  has  led  to  several  disastrous  situations  in  pediatric  care.  Variations  in  absorption  of  medications  from  the  gastrointestinal  tract,  intramuscular  injection  sites,  and  skin  are  important  in  pediatric  patients,  especially  in  premature  and  other  newborn  infants.  The  rate  and  extent  of  organ  function  development  and  the  distribution,  metabolism,  and  elimination  of  drugs  differ  not  only  between  pediatric  versus  adult  patients  but  also  among  pediatric  age  groups.  The  effectiveness  and  safety  of  drugs  may  vary  among  age  groups  and  from  one  drug  to  another  in  pediatric  versus  adult  patients.  Concomitant  diseases  may  influence  dosage  requirements  to  achieve  a  targeted  effect  for  a  specific  disease  in  children.  Use  of  weight-based  dosing  of  medications  for  obese  children  may  result  in  suboptimal  drug  therapy.  The  myth  that  neonates  and  young  infants  do  not  experience  pain  has  led  to  inadequate  pain  management  in  this  pediatric  population.  Special  methods  of  drug  administration  are  needed  for  infants  and  young  children.  Many  medicines  needed  for  pediatric  patients  are  not  available  in  appropriate  dosage  forms;  thus,  the  dosage  forms  of  drugs  marketed  for  adults  may  require  modification  for  use  in  infants  and  children,  necessitating  assurance  of  potency  and  safety  of  drug  use.  The  pediatric  medication-use  process  is  complex  and  error  prone  because  of  the  multiple  steps  required  in  calculating,  verifying,  preparing,  and  administering  doses.