RT Book, Section
A1 Reus, Victor I.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1180526808
T1 Depression and Depressive Disorders
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accesspharmacy.mhmedical.com/content.aspx?aid=1180526808
RD 2024/04/16
AB Mood  disorders  are  characterized  by  a  disturbance  in  the  regulation  of  mood,  behavior,  and  affect.  Mood  disorders  are  subdivided  into  (1)  depressive  disorders,  (2)  bipolar  disorders,  and  (3)  depression  in  association  with  medical  illness  or  alcohol  and  substance  abuse  (Chaps.  445,  Chaps.  446,  Chaps.  447,  448).  Major  depressive  disorder  (MDD)  is  differentiated  from  bipolar  disorder  by  the  absence  of  a  manic  or  hypomanic  episode.  The  relationship  between  pure  depressive  syndromes  and  bipolar  disorders  is  not  well  understood;  MDD  is  more  frequent  in  families  of  bipolar  individuals,  but  the  reverse  is  not  true.  In  the  Global  Burden  of  Disease  Study  conducted  by  the  World  Health  Organization,  unipolar  major  depression  ranked  fourth  among  all  diseases  in  terms  of  disability-adjusted  life-years  and  was  projected  to  rank  second  by  the  year  2020.  In  the  United  States,  lost  productivity  directly  related  to  mood  disorders  has  been  estimated  at  $55.1  billion  per  year.