RT Book, Section
A1 Beck Jr., Laurence H.
A1 Salant, David J.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1177731327
T1 Chronic Tubulointerstitial Diseases of the Kidney
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accesspharmacy.mhmedical.com/content.aspx?aid=1177731327
RD 2024/04/19
AB Improved  occupational  and  public  health  measures,  together  with  the  banning  of  over-the-counter  phenacetin-containing  analgesics,  has  led  to  a  dramatic  decline  in  the  incidence  of  chronic  interstitial  nephritis  (CIN)  from  heavy  metal—particularly  lead  and  cadmium—exposure  and  analgesic  nephropathy  in  North  America.  Today,  CIN  is  most  often  the  result  of  renal  ischemia  or  secondary  to  a  primary  glomerular  disease  (Chap.  308).  Other  important  forms  of  CIN  are  the  result  of  developmental  anomalies  or  inherited  diseases  such  as  reflux  nephropathy  or  sickle  cell  nephropathy  and  may  not  be  recognized  until  adolescence  or  adulthood.  Although  it  is  impossible  to  reverse  damage  that  has  already  occurred,  further  deterioration  may  be  prevented  or  at  least  slowed  in  such  cases  by  treating  glomerular  hypertension,  a  common  denominator  in  the  development  of  secondary  FSGS  and  progressive  loss  of  functioning  nephrons.  Therefore,  awareness  and  early  detection  of  patients  at  risk  may  prevent  them  from  developing  end-stage  renal  disease  (ESRD).