RT Book, Section A1 Smith, Martyn T. A1 McHale, Cliona M. A2 Klaassen, Curtis D. A2 Watkins, John B. SR Print(0) ID 1178014254 T1 Toxic Responses of the Blood T2 Casarett & Doull’s Essentials of Toxicology, 4e YR 2021 FD 2021 PB McGraw Hill PP New York, NY SN 9781260452297 LK accesspharmacy.mhmedical.com/content.aspx?aid=1178014254 RD 2024/03/28 AB KEY POINTSHematotoxicology is the study of adverse effects of exogenous chemicals on blood and blood-forming tissues.Direct or indirect damage to blood cells and their precursors includes tissue hypoxia, hemorrhage, and infection.Xenobiotic-induced aplastic anemia is a life-threatening disorder characterized by peripheral blood pancytopenia, reticulocytopenia, and bone marrow hypoplasia.Idiosyncratic xenobiotic-induced agranulocytosis may involve a sudden depletion of circulating neutrophils concomitant with exposure that persists as long as the agent or its metabolites are in the circulation.Leukemias are proliferative disorders of hematopoietic tissue that originate from individual bone marrow cells.Xenobiotic-induced thrombocytopenia may result from increased platelet destruction or decreased platelet production, which lead to decreased platelet aggregation and bleeding disorders.Blood coagulation is a complex process involving a number of proteins whose synthesis and function can be altered by many xenobiotics.