RT Book, Section
A1 Campen, Matthew J.
A2 Klaassen, Curtis D.
A2 Watkins, John B.
SR Print(0)
ID 1178015532
T1 Toxic Responses of the Heart and Vascular System
T2 Casarett & Doull’s Essentials of Toxicology, 4e
YR 2021
FD 2021
PB McGraw Hill
PP New York, NY
SN 9781260452297
LK accesspharmacy.mhmedical.com/content.aspx?aid=1178015532
RD 2024/04/20
AB KEY  POINTSTypical  chemical-induced  disturbances  in  cardiac  function  consist  of  effects  on  heart  rate  (chronotropic),  contractility  (inotropic),  conductivity  (dromotropic),  and/or  excitability  (bathmotropic).Any  xenobiotic  that  disrupts  ion  movement  or  homeostasis  may  induce  a  cardiotoxic  reaction  composed  principally  of  disturbances  in  heart  rhythm.All  toxicants  absorbed  into  the  circulatory  system  contact  vascular  cells  before  reaching  other  sites  in  the  body.Common  mechanisms  of  vascular  toxicity  include  (1)  alterations  in  membrane  structure  and  function,  (2)  redox  stress,  (3)  vessel-specific  bioactivation  of  protoxicants,  and  (4)  preferential  accumulation  of  the  active  toxin  in  vascular  cells.