RT Book, Section A1 Belsito, Donald V. A2 Klaassen, Curtis D. A2 Watkins, John B. SR Print(0) ID 1178015655 T1 Toxic Responses of the Skin T2 Casarett & Doull’s Essentials of Toxicology, 4e YR 2021 FD 2021 PB McGraw Hill PP New York, NY SN 9781260452297 LK accesspharmacy.mhmedical.com/content.aspx?aid=1178015655 RD 2024/03/29 AB KEY POINTSSkin participates directly in thermal, electrolyte, hormonal, metabolic, and immune regulation.Percutaneous absorption depends on the xenobiotic’s hydrophobicity, which affects its ability to partition into epidermal lipid, and rate of diffusion through this barrier.Cells of the epidermis and pilosebaceous units express biotransformation enzymes.Irritant dermatitis is a nonimmune-related response caused by the direct action of a chemical on the skin.Allergic contact dermatitis represents a delayed (type IV) hypersensitivity reaction, whereby minute quantities of material elicit overt reactions.