RT Book, Section A1 Ufelle, Alexander C. A1 Barchowsky, Aaron A2 Klaassen, Curtis D. A2 Watkins, John B. SR Print(0) ID 1178016466 T1 Toxic Effects of Metals T2 Casarett & Doull’s Essentials of Toxicology, 4e YR 2021 FD 2021 PB McGraw Hill PP New York, NY SN 9781260452297 LK accesspharmacy.mhmedical.com/content.aspx?aid=1178016466 RD 2024/03/28 AB KEY POINTSPersons at either end of the life span, young children or elderly people, are more susceptible to toxicity from exposure to a particular level of metal than most adults.Metals that provoke immune reactions include mercury, gold, platinum, beryllium, chromium, and nickel.Complexation is the formation of a metal ion complex in which the metal ion is associated with a charged or uncharged electron donor, referred to as a ligand.Chelation occurs when bidentate ligands form ring structures that include the metal ion and the two ligand atoms attached to the metal.Metal–protein interactions include binding to numerous enzymes, the metallothioneins, nonspecific binding to proteins such as serum albumin or hemoglobin, and specific metal carrier proteins involved in the membrane transport of metals.