RT Book, Section
A1 Mount, David B.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1178487157
T1 Hypernatremia
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accesspharmacy.mhmedical.com/content.aspx?aid=1178487157
RD 2024/04/19
AB Hypernatremia  is  defined  as  an  increase  in  the  plasma  Na+  concentration  to  >145  mM.  Considerably  less  common  than  hyponatremia,  hypernatremia  is  nonetheless  associated  with  mortality  rates  of  as  high  as  40–60%,  mostly  due  to  the  severity  of  the  associated  underlying  disease  processes.  Hypernatremia  is  usually  the  result  of  a  combined  water  and  electrolyte  deficit,  with  losses  of  H2O  in  excess  of  Na+.  Less  frequently,  the  ingestion  or  iatrogenic  administration  of  excess  Na+  can  be  causative,  for  example  after  IV  administration  of  excessive  hypertonic  Na+-Cl–  or  Na+-HCO3–(Fig.  49-6).