RT Book, Section
A1 Mount, David B.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1178487224
T1 Hyperkalemia
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accesspharmacy.mhmedical.com/content.aspx?aid=1178487224
RD 2024/04/25
AB Hyperkalemia  is  defined  as  a  plasma  potassium  level  of  5.5  mM,  occurring  in  up  to  10%  of  hospitalized  patients;  severe  hyperkalemia  (>6.0  mM)  occurs  in  ~1%,  with  a  significantly  increased  risk  of  mortality.  Although  redistribution  and  reduced  tissue  uptake  can  acutely  cause  hyperkalemia,  a  decrease  in  renal  K+  excretion  is  the  most  frequent  underlying  cause  (Table  49-5).  Excessive  intake  of  K+  is  a  rare  cause,  given  the  adaptive  capacity  to  increase  renal  secretion;  however,  dietary  intake  can  have  a  major  effect  in  susceptible  patients,  e.g.,  diabetics  with  hyporeninemic  hypoaldosteronism  and  chronic  kidney  disease.  Drugs  that  impact  on  the  renin-angiotensin-aldosterone  axis  are  also  a  major  cause  of  hyperkalemia.