RT Book, Section
A1 Langford, Carol A.
A1 Fauci, Anthony S.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1178487713
T1 Single-Organ Vasculitis
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accesspharmacy.mhmedical.com/content.aspx?aid=1178487713
RD 2024/04/18
AB The  potential  for  vasculitis  to  affect  single  organs  has  become  increasingly  recognized.  This  has  been  defined  as  vasculitis  in  arteries  or  veins  of  any  size  in  a  single  organ  that  has  no  features  that  indicate  that  it  is  a  limited  expression  of  a  systemic  vasculitis.  Examples  include  isolated  aortitis,  testicular  vasculitis,  vasculitis  of  the  breast,  isolated  cutaneous  vasculitis,  and  primary  CNS  vasculitis.  In  some  instances,  this  may  be  discovered  at  the  time  of  surgery  such  as  orchiectomy  for  a  testicular  mass  where  there  is  concern  for  neoplasm  that  is  found  instead  to  be  vasculitis.  Some  patients  originally  diagnosed  with  single-organ  vasculitis  may  later  develop  additional  manifestations  of  a  more  systemic  disease.  In  instances  where  there  is  no  evidence  of  systemic  vasculitis  and  the  affected  organ  has  been  removed  in  its  entirety,  the  patient  may  be  followed  closely  without  immunosuppressive  therapy.  In  other  instances,  such  as  primary  CNS  vasculitis  or  some  patients  with  isolated  cutaneous  vasculitis,  medical  intervention  is  warranted.