RT Book, Section A1 Schwinghammer, Terry L. A1 DiPiro, Joseph T. A1 Ellingrod, Vicki L. A1 DiPiro, Cecily V. SR Print(0) ID 1178895976 T1 Heart Failure T2 Pharmacotherapy Handbook, 11e YR 2021 FD 2021 PB McGraw Hill PP New York, NY SN 9781260116694 LK accesspharmacy.mhmedical.com/content.aspx?aid=1178895976 RD 2024/04/23 AB Heart failure (HF) is a progressive syndrome that can result from any changes in cardiac structure or function that impair the ability of the ventricle to fill with or eject blood. HF may be caused by an abnormality in systolic function, diastolic function, or both. HF with reduced systolic function (ie, reduced left ventricular ejection fraction, LVEF) is referred to as HF with reduced ejection fraction (HFrEF). Preserved LV systolic function (ie, normal LVEF) with presumed diastolic dysfunction is termed HF with preserved ejection fraction (HFpEF).