RT Book, Section A1 Katzung, Bertram G. A1 Kruidering-Hall, Marieke A1 Trevor, Anthony J. SR Print(0) ID 1179217609 T1 Histamine, Serotonin, Drugs Used in Obesity, & the Ergot Alkaloids T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 12e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259641022 LK accesspharmacy.mhmedical.com/content.aspx?aid=1179217609 RD 2024/03/28 AB Autacoids are endogenous molecules that do not fall into traditional autonomic groups. They do not act on cholinoceptors or adrenoceptors but have powerful pharmacologic effects on smooth muscle and other tissues. Histamine and serotonin (5-hydroxytryptamine; 5-HT) are the most important amine autacoids. The drugs used in obesity do not have significant smooth muscle effects but have some properties in common with the histamine and serotonin groups. The ergot alkaloids are a heterogeneous group of drugs (not autacoids) that interact with serotonin receptors, dopamine receptors, and α receptors. They are included in this chapter because of their effects on serotonin receptors and on smooth muscle. Peptide and eicosanoid autacoids are discussed in Chapters 17 and 18. Nitric oxide is discussed in Chapter 19.