RT Book, Section A1 Katzung, Bertram G. A1 Kruidering-Hall, Marieke A1 Trevor, Anthony J. SR Print(0) ID 1179223629 T1 Agents That Affect Bone Mineral Homeostasis T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 12e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259641022 LK accesspharmacy.mhmedical.com/content.aspx?aid=1179223629 RD 2024/03/29 AB Calcium and phosphorus, the 2 major elements of bone, are crucial not only for the mechanical strength of the skeleton but also for the normal function of many other cells in the body. Three hormones are the main regulators of calcium and phosphate homeostasis, parathyroid hormone (PTH), vitamin D, and fibroblast growth factor 23 (FGF23) (Figure 42–1). Calcitonin, glucocorticoids, and estrogens play secondary roles. These hormones, or drugs that mimic or suppress their actions, are used in the treatment of bone mineral disorders (eg, osteoporosis, rickets, osteomalacia, Paget’s disease), as are several nonhormonal agents.