RT Book, Section
A1 Hecht, Keith A.
A2 Sutton, S. Scott
SR Print(0)
ID 1179733478
T1 Lung Cancer
T2 McGraw Hill’s NAPLEX® Review Guide, 4e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781264258062
LK accesspharmacy.mhmedical.com/content.aspx?aid=1179733478
RD 2024/04/19
AB Lung  carcinomas  arise  from  normal  bronchial  cells  that  have  acquired  multiple  genetic  lesions  and  are  capable  of  expressing  a  variety  of  phenotypes.  There  are  four  major  subtypes  of  lung  cancer:  small  cell,  squamous  cell,  adenocarcinoma,  and  large  cell.  Squamous  cell,  adenocarcinoma,  and  large  cell  are  collectively  referred  to  as  non–small-cell  lung  cancer  (NSCLC).  NSCLC  represents  85%  of  the  lung  cancer  diagnoses  while  the  aggressive  histology  small-cell  lung  cancer  (SCLC)  represents  15%  of  lung  cancer  diagnoses.  Adenocarcinoma  is  the  most  common  histology  of  NSCLC  (50%  of  all  lung  cancer)  and  is  associated  with  a  high  incidence  of  distant  metastasis  at  diagnosis.  Squamous  cell  is  the  second  most  common  histology  of  NSCLC  (30%  of  all  lung  cancer)  followed  by  large  cell.  Adenocarcinoma  and  large-cell  lung  cancer  generally  present  as  peripheral  lesions  in  the  lung,  whereas  squamous  cell  and  small  cell  histologies  commonly  present  as  central  lesions,  often  causing  hemoptysis  or  postobstructive  pneumonia.