RT Book, Section A1 Roccograndi, Laura A2 Sutton, S. Scott SR Print(0) ID 1179734081 T1 Urinary Tract Infections T2 McGraw Hill’s NAPLEX® Review Guide, 4e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781264258062 LK accesspharmacy.mhmedical.com/content.aspx?aid=1179734081 RD 2024/04/19 AB A urinary tract infection (UTI) is defined as microbial infiltration that cannot be accounted for by contamination in an otherwise sterile urinary tract. UTIs encompass infections of the lower urinary tract, upper urinary tract, and kidneys with risk factors consisting of age, sex, pregnancy, diabetes, urinary catheter, and vaginal intercourse. Lower tract UTIs (cystitis) start with periurethral contamination by uropathogens residing in the gut. Upper tract UTIs (pyelonephritis) develop when uropathogens ascend to the kidneys. UTIs are further classified as uncomplicated or complicated. Uncomplicated UTIs are infections occurring in women of childbearing age with structurally and neurologically normal urinary tracts. Complicated UTIs occur in patients with functional or structural abnormalities. Additionally, UTIs in men, pregnant women, children, and patients in health care-associated settings are considered complicated.