RT Book, Section A1 Bolina, Jasleen A1 Branan, Trisha N. A2 Sutton, S. Scott SR Print(0) ID 1179734214 T1 Sepsis Syndromes T2 McGraw Hill’s NAPLEX® Review Guide, 4e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781264258062 LK accesspharmacy.mhmedical.com/content.aspx?aid=1179734214 RD 2024/04/18 AB Sepsis is a continuum of physiologic stages characterized by infection, systemic inflammation, and hypoperfusion leading to tissue injury and organ failure (Table 26-1 for definitions to use for sepsis syndromes). Risk factors for sepsis include extremes of age, cancer, immunodeficiency, chronic organ failure, genetic factors (male and non-white ethnic origin in North America), patients with bacteremia, and genetic polymorphisms associated with immune regulation. Pulmonary, gastrointestinal, genitourinary, and bloodstream infections account for the majority of sepsis cases.